Clinical Neurology and Neuroscience

Special Issue

Biomarkers in Dementia, Mood Depressive Disorders, Bipolar Disorders, Schizophrenia

  • Submission Deadline: May 30, 2022
  • Status: Submission Closed
  • Lead Guest Editor: Fabio Panariello
About This Special Issue
Severe Mental Illnesses (SMIs) are among the most impactful and disabling disease worldwide. The only Mood Depressive Disorder (MDD) ranks as the fourth cause of the global burden of disease. Patients affected by SMIs quite often experience cognitive function impairment with consistent attention and/or memory complaints such as patients affected by Dementia. Several lines of evidences have pointed out that the dysregulation of the stress system in reaction at the environment dynamic contributes to the onset of the SMIs.
Increasing scientific corroborations have highlighted that the amendment of several biological pathways underlies the pathophysiology of different SMIs. It is now quite properly recognized that disruption of the innate and adaptive immune systems may be found in patients affected by SMIs and Dementia and it could impact on the response status to the specific treatment. Consistently with these findings, a piece of research has focused on the identification of peripheral biomarkers in line with the dysregulation of immune system, such as cytokines, hypothalamic-pituitary adrenal axis, glucocorticoid and corticotropin-releasing factor , in order to help the diagnostic process, to survey response to the treatments and to better know the biological pictures underpinning the SMIs. By considering the relevant role of inflammation and alteration of other biological pathways in SMIs pathophysiology, the primary aim of this special issue is to collect evidences of biomarkers in SMIs. The secondary aim is to better understand if it could be evidence based further studies on the involvement of specific biomarkers in the pathogenesis of SMIs or on the role specific biomarker in the prediction of SMIs and response state to the treatments.

Keywords:

  1. Mood Depressive Disorders
  2. Schizophrenia
  3. Dementia
  4. Biomarkers
  5. Inflammation
  6. Response prediction
Lead Guest Editor
  • Fabio Panariello

    Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy